Sessions

 

Session 38

 

Thursday, September 3

10:30 am – 12:30 pm

Room: Genevoix    

The inlet and outlet valves

Sphincteric issues

     
Chairs: James G. Brasseur (USA) – Larry S. Miller (USA)

Discussant: Ingo F. Herrmann (Germany)

 

• How can the "functional luminal imaging probe" (FLIP) technologies be used to provide both fundamental understanding and clinically useful data on the mechanics of the pharyngo-esophageal segment, both in its protective function and especially in relationship to dysfunction? Julie Regan (Ireland)
• Selective stimulation of intrinsic excitatory and inhibitory motor pathways in the LOS.
  Pere Clave (Spain)
• What is the detailed physiology of the different muscle groups of the gastro-esophageal segment that contribute to the maintenance of luminal squeeze pressures in the resting state that protect the lower esophagus against reflux? Michael R. Ruggieri (USA)
• What are examples of mechanical vs. neurological dysfunctions of the lower esophageal sphincter including the anatomical and/or physiological abnormalities associated with the dysfunction, and diagnostic/therapeutic consequences of the dysfunction? Jack Wood (USA)
• How can the "functional luminal imaging probe" (FLIP) technologies be used to provide both fundamental understanding and clinically useful data on the mechanics of the lower esophageal segment (high-pressure zone), both in its protective function and especially in relationship to dysfunction?
  Barry P. McMahon (Ireland)
• How can mathematical and computer modeling studies of the pharngo-esophageal segment be used to provide both fundamental and clinically useful knowledge on the physiology and function of the upper esophageal sphincter, both in its protective function and especially in relationship to dysfunction?
  Rohan B.H. Williams (Singapore)
• What is the detailed anatomical structure of the various muscle groups spanning the gastro-esophageal segment, the orientation of the muscle fibers, the muscle fiber types and synaptic structure, and the anatomical relationship of these different muscle fiber groups to each other and to the overall structure of the esophagus, gastric cardia, crural and costal diaphragms, phreno-esophageal ligament, and transition in mucosal cell type? Larry S. Miller (USA)
• What changes in the anatomic and physiological state of the different muscle groups of the gastro-esophageal segment cause reductions in squeeze pressure within the body of the lower esophagus and at the junction between the esophagus and gastric cardia, and how are these related to normal and abnormal function? Larry S. Miller (USA)
• How can mathematical and computer modeling studies of the gastro-esophageal segment be used to provide both fundamental and clinically useful knowledge on the physiology and function of the gastro-esophageal segment, both in its protective function and especially in relationship to dysfunction?
  James G. Brasseur (USA)
• How, when and why do axial motions of the intrinsic and extrinsic muscle groups in the gastro-esophageal segment contribute to changes in closure pressure of the lower esophageal sphincter, and what are the sources of these axial motions? James G. Brasseur (USA)