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 • Scientific Committee
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• PS1 Physiology
• PS2 Pathophysiology
• PS3 Investigations
• PS4 Investigations (Cont.)
...........Symptomatology
• PS5 Extra-esophageal symptoms
...........ENT symptoms
• PS6 Pulmonary symptoms
• PS7 Histology
...........Medical Treatments

PS2 Pathophysiology Monday, September 1, 2003
Presidents: R.K. MITTAL (USA)
G. TRIADAFILOPOULOS (USA)

10:30 a.m.
10:40 a.m.
 Key note address: R.K. MITTAL (San Diego)
The probe ultra-sonography in the assessment of esophageal sensation and motility disorders.

Can DGER cause symptoms of its own or worsen those produced by acid reflux?
P.O. KATZ (Philadelphia)

In patients with GERD, what is the proportion of bile reflux events associated with acid reflux?
D. SIFRIM (Leuven)

What are the differences in the esophageal clearance of acid and of duodenal content in patients with severe reflux disease?
J. TACK (Leuven)

Is there a correlation between alkaline exposure time and DGER?
Can it be considered as a marker?
J. TACK (Leuven)

What are the limitations of the evaluation of bile reflux in vivo?
M. VAEZI (Cleveland)

11:05 a.m.
11:15 a.m.

I. HERRMANN (Italy)


What is the relationship between the conjugation of bile acids and the pH of the refluxate?
D. NEHRA (Surrey)

Is there a correlation between the detrimental effects of bile reflux and the pH of the refluxate?
P. BECHI (Florence)

Is isolated bile reflux associated with significant mucosal damage?
C.G. BREMNER (Los Angeles)

What are the experimental effects of trypsin inhibitors on alkaline reflux esophagitis following total gastrectomy?
T. IMADA (Yokohama)
 
11:40 a.m.
11:50 a.m.

T.N. WALSH (Dublin)
What is the relationship between pH, ionization, and deleterious effects of bile salts and trypsin on the esophageal mucosa?
M. COSTANTINI (Padova)

What are the compared morphological injurious effects of bile salts, trypsin, an pepsin, isolated or in combination, on the esophageal mucosa?
J. SALO (Helsinki)

What is their respective damage on mucosal barrier disruption?
J. SALO (Helsinki)

Does the possible barrier disruption without morphological damage suggest the existence of diverse mechanisms of damage?
R.F. SOUZA (Dallas)

Do Cytokines (interleukine, tumor necrosis factor, macrophage inflammatory protein) play a role in the esophageal inflammatory process following DGER?
R.FITZGERALD (Cambridge)


12:15
Topic Forum
 Is the term alkaline reflux a misnomer?
M.VAEZI (Cleveland) A. DEL GENIO (Naples)
12:25 p.m.

 

12:30 p.m.
 LUNCH